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Frontiers in Bioengineering and Biotechnology
년도 2024
학술지명 Frontiers in Bioengineering and Biotechnology
논문명 Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease
게재권/집 Volume 12 - 2024
수록페이지
저자명 Jeongrak Park, Seongtak Kang, Yaebin Lee, Ji-Woong Choi, Yong-Seok Oh
Link 관련링크 https://www.frontiersin.org/articles/10.3389/fbioe.2024.1335474/full 721회 연결
Levodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset of LID. Using in vivo fast-scan cyclic voltammetry and second-derivative-based background drift removal, we continuously measured tonic dopamine levels using high temporal resolution recording over 1-h. Increases to tonic dopamine levels following acute levodopa administration were slow and marginal within the naïve PD model. However, these levels increased faster and higher in the LID model. Furthermore, we identified a strong positive correlation of dyskinetic behavior with the rate of dopamine increase, but much less with its cumulative level, at each time point. Here, we identified the altered signature of striatal DA dynamics underlying LID in PD using an advanced FSCV technique that demonstrates the long-range dynamics of tonic dopamine following drug administration.